Vol. 2, Issue 2 (2017)
Evaluation of oral contraceptives in development of premalignant cervix lesions
Author(s): Karen Olivia Bazzo, Raiane T Silva, Thaís Oliveira Da Cruz, Davilyn Conte, Fernanda Scatola, Alessandra Eifler Guerra Godoy
Abstract: Background: Cervical cancer (CC) is among the most prevalent carcinomas, it is related to infection with human papillomavirus (HPV). In literature there are conflicting data on the use of oral contraceptives (COC) as a risk factor for the development of CC. Based on the data above, this study aimed at analyzing the results of cytopathology (CP) and pathological (AP) analysis and their association with the use of COC. Methods: 153 patients were asked about the use of COC. Afterwards, the results of the questions were compared to CP and AP examinations. Results: The use of COC, especially in periods longer than three months, is associated with increased frequency of low and high grade squamous intraepithelial lesion in CP and AP exams, which is most apparently influent in the age group 25-45 years. Conclusion: Present data suggest that the use of COC for more than three months may represent a risk factor for the emergence of cervical cancer precursor lesions.