International Journal of Advanced Research and Development

Authors
Vijayalakshmi P, Radha R

Abstract
Alzheimer’s disease is a progressive, neurodegenerative disorder that primarily affects the elderly population responsible for 60% of all dementia in people aged 65 or older. The present study deals with the pharmacological activity of fruit peels of Citrus maxima (J. Burm.) Merr. in Scopolamine induced Alzheimer’s disease. Animals were maintained as per ethical guidelines for animal protection and welfare, bearing the Resolution No. 05/243/CPCSEA. Dt: 10/08/2015. The mice were divided into four groups and changes in behavioral aspects were analyzed by using Morris maze and Y Maze method. The studies were performed using Rivastigmine as standard. The whole brain after the studies were homogenized and examined for acetyl cholinesterase level. The results revealed the Anti Alzheimer activity of ethanolic extract Citrus maxima peel, with decrease in the brain acetyl cholinesterase level. Which could be considered as an effective tool for the treatment of Alzheimer’s.