Brain histopathology of the fish Cyprinus carpio exposed to lethal concentrations of an organophosphate insecticide phorate
Cyprinus carpio (C. carpio) fish were exposed to acute lethal toxicity of phorate (ALTP) and its effect on the histopathological responses of the brain of the fresh water fish was investigated in the present study. Fish were exposed to ALTP (LC50/96 hours - 0.71 ppm/l) for one day and 4 days and the differential acute toxicity tests were carried out under laboratory conditions. On exposure for a period of 1 day to ALTP, mild degenerative changes were observed in the neural cells of the brain of fish. Initiation of the degeneration in the neural cells and structural degeneration was observed. On exposure for a period of 4 days, there was a further increase in the structural damage in the brain. Necrosis of neurons, intracellular oedema, congestion and degeneration of neural cells with the cytoplasmic vacuolization were observed. On exposure to ALTP, though initially it caused a mild damage to the brain of the fish at day 1 but further exposure to ALTP for 4 days, it caused a pronounced damage. The frequency and intensity of tissue lesions in the brain depend on the concentration of the pesticide as well as the length of the fish exposure period to the pesticide.
G Lakshmaiah. Brain histopathology of the fish Cyprinus carpio exposed to lethal concentrations of an organophosphate insecticide phorate. International Journal of Advanced Research and Development, Volume 2, Issue 5, 2017, Pages 668-672